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However, very high doses unlikely providing proportionally greater benefits due to receptor saturation

3c,d and Extended Data Fig

Not for human or animal use, and not suitable for medical, diagnostic, or therapeutic purposes

In Phase 3 clinical trials (REDEFINE 1 and REDEFINE 2), the cagrilintide and semaglutide combination was administered once weekly via subcutaneous injection, with dose escalation targeting 2.4 mg of each peptide weekly over a 68-week trial duration

Semaglutide Semaglutide marketed as Ozempic for type 2 diabetes and Wegovy for chronic weight management is the most widely studied GLP-1 agonist in PCOS at this point