The process of glucuronic acid conjugation usually terminates the pharmacological activity of drugs but in some cases drug is converted into an active form
This theory has been augmented by several studies that demonstrated increased markers of oxidative stress (by-products of non-enzymatic lipid peroxidation) in children suffering from konzo as well as documentation of deficiencies in micronutrients which are required to maintain effective antioxidant response in konzo-prone populations 18,19
StatPearls [Internet] (2020)
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