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Nature 569 , 570575 (2019)

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Most patients are diagnosed in the early weeks of treatment and have no symptoms or only mild signs

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Epigenetic Regulation Through Methylation 5-Amino-1MQ enables investigation of NNMTs role in methylation homeostasis: SAM/SAH Ratio: Measurement of methylation capacity through SAM and SAH quantification Global DNA Methylation: Studies on genomic methylation patterns Histone Methylation: Investigation of histone methyltransferase activity and histone marks Gene Expression: Examination of methylation-sensitive gene regulation Metabolic Reprogramming: Research on epigenetic contribution to metabolic phenotype Research addresses whether NNMT competes for SAM with other critical methyltransferases