10.4291/wjgp.v11.i1.1 23 GongG.WangP.DingW.ZhaoY.LiJ
10.1096/fasebj.31.1_supplement.993.3 Abstract retrieved fromExperimental Biology 2017 Meeting [DOI] [Google Scholar] Krivic A., Anic T., Seiwerth S., Huljev D., Sikiric P
Common Symptoms of B12 Deficiency When Vitamin B12 levels drop too low you can experience a variety of symptoms including: Impaired mental functionality poor memory, brain fog, confusion, anxiety, irritability Muscular weaknesses overall muscle weakness, tender calves, numbness and/or tingling in your extremities, Sensations of pins and needles due to nerve damage, Glossitis and mouth ulcers, Mood changes: depression, psychosis and irritability, Some loss in sense of touch, walking and vision problems, Appetite Changes Loss of appetite and weight loss, anemia, Low energy general fatigue (especially in the afternoon), shortness of breath, pale or yellowing complexion, Migraine-like Symptoms lightheadedness, dizziness, blurry vision, sensitivity to light, etc What Causes a Vitamin B12 Deficiency
Half-life & frequency rationale No published human pharmacokinetic study of 5-Amino-1MQ exists, and the mouse efficacy study itself did not report half-life or bioavailability figures
You might be eating well, supplementing well, and still feel really depleted, because the issue is not about intake, its just about absorption