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Each cycle of 13% O 2 hypoxic treatment for 5 min was followed by 21% O 2 normoxia for 5 min

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BDNF and proBDNF appear to be linked to craving and relapse risk in early withdrawal periods, but the persistence of higher levels over several months reveals a deeper and more complex disruption of neurotrophin production, reflecting enduring and long-term reactive structural and functional changes in neurotrophic equilibrium

What makes it unique is its dual capacity: enhancing immunity when needed while dampening excessive inflammation

10.1210/en.136.5.2214 Endocrinology 83 SapolskyR