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As TP53 mutations are strong drivers of negative outcomes in multiple hematologic malignancies, as exemplified by relapsed pediatric acute lymphoblastic leukemia, APR-246 may likely have more broad clinical implications including synergy with traditional cytotoxic agents, as has been recently described.20 Together, shedding light on the synergistic mechanisms underlying APR-246 and azacitidine therapy as presented in this study are critical to continue to advance this novel therapeutic option for patients with the poorest outcomes to traditional treatments

no serious adverse effects in that group

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It was derived from research on melanotan II a peptide initially developed for sunless tanning that unexpectedly induced sexual arousal and erections in early tests

I am not certain why this happens, and it doesn't appear to have a lasting effect