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But the menthol smokers had more frequent severe exacerbations: 0.22 per year, versus 0.18 per year among smokers of regular tobacco cigarettes

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However, we believe that as shown, NLRP6-dependent perturbation of the gut microbiome may generate specific metabolites or compounds ( Our study supports evidence of an altered gut microbiota between WT and Nlrp6 -/- mice as previously reported ( In addition, two independent studies showed that NLRP6 deficiency led to impaired intestinal mucus secretion, disrupted mucus barrier, and mucosal surface invasion by enteric pathogens and finally to dysbiosis ( -/- mice

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