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Unlike disulfide linkers, which rely on intracellular glutathione (GSH) levels, acid cleavable linkers are entirely triggered by acidic environments, making them less dependent on variable intracellular redox states

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After injection, oocytes were arrested for 18 h in M2 medium containing 2.5 M milrinone (S2484, Selleck) to allow complete degradation of Pcbp1 mRNA

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Glutamine, as a precursor of glutathione, and oxidative stress

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In addition, the GSH:GSSG ratio is critical for creating cellular compartments with unique redox characteristics

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