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To further test the crucial role of GSH in the acute phase of colitis, we analyzed the effect of NAC, a GSH precursor, on mucosal GSH levels in relation with the TNBS-induced colitis

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Each time a cell divides, telomeres shorten, eventually triggering cellular senescence or apoptosis - effectively limiting the replicative lifespan of normal somatic cells to approximately 50-70 divisions (the Hayflick limit)