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doi: 10.3168/jds.S0022-0302(98)75612-7 34 KampenAHTollersrudTLarsenSRothJAFrankDELundA

Decreased CBF observed in the early stages of AD, non-demented PD patients, ALS cases before cognitive decline, and in normally appearing white matter of MS patients without cognitive impairments, implies that CBF reduction may serve as an early biomarker, preceding neurodegenerative changes

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