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The researchers found that adding the antioxidants N-acetylcysteine (NAC) or vitamin E to the diet of mice with small lung tumors substantially increased the number, size, and stage of the tumors

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Together, these studies highlight the complex interplay between CKD, neuroinflammation, and gut-derived signals, providing strong evidence that the gut microbiota and its metabolites play a significant role in promoting neuroinflammatory processes in CKD, which in turn contribute to cognitive decline and neurodegenerative changes