Elez E, Yoshino T, Shen L, Lonardi S, Cutsem EV, Eng C, Kim TW, Wasan HS, Desai J, Ciardiello F, Yaeger R, Maughan TS, Van K Morris II, Wu C, Usari T, Laliberte RJ, Dychter SS, Zhang X, Tabernero J, Kopetz S
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Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990