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Similar content being viewed by others Introduction Gastric cancer (GC) is the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, with an annual global incidence surpassing one million newly diagnosed cases [1]

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Glossary AAs African Americans ACCORD-MIND Action to Control Cardiovascular Risk in Diabetes-Memory in Diabetes ACE angiotensin-converting enzyme AGE advanced glycation end product Agt angiotensinogen Ang I angiotensin I Ang II angiotensin II APOL1 apolipoprotein L1 APP/PS1 amyloid precursor protein/presenilin 1 ARB angiotensin receptor blocker ARIC Atherosclerosis Risk in Communities AT1R angiotensin II type 1 receptor BBB blood-brain barrier BRINK Brain in Kidney Disease Cho choline CKD chronic kidney disease CRP C-reactive protein CSF cerebrospinal fluid cSVD cerebral small vessel disease CX3CR1 C-X3-C motif chemokine receptor 1 DC diabetic cognopathy DCCT Diabetes Control and Complications Trial DKD diabetic kidney disease DM diabetes mellitus DPP-4 dipeptidyl peptidase 4 eGFR estimated glomerular filtration rate ESRD end-stage renal disease FGF-23 fibroblast growth factor 23 FIDELIO-DKD Finerenone in Reducing Kidney Failure and Disease Progression in Diabetic Kidney Disease FIGARO-DKD Finerenone in Reducing Cardiovascular Mortality and Morbidity in Diabetic Kidney Disease GLP-1 glucagon-like peptide 1 GM gray matter HbA1c glycosylated hemoglobin IL-1 interleukin-1 IL-6 interleukin-6 INVADE Intervention Project on Cerebrovascular Diseases and Dementia in the community of Ebersberg LADIS Leukoaraiosis and Disability Study Lp-PLA2 lipoprotein-associated phospholipase A2 MGCs microglial cells MMSE Mini-Mental State Examination MoCA Montreal Cognitive Assessment MRA mineralocorticoid receptor antagonist MRI magnetic resonance imaging mTOR mammalian target of rapamycin NAA N-acetyl aspartate NAME Nutrition, Aging, and Memory in Elders NHANES III Third National Health and Nutrition Examination Survey Nrf2 nuclear factor erythroid 2-related factor 2 RAAS renin-angiotensin-aldosterone system RAGE receptor for AGE RAS renin-angiotensin system RBP4 retinol-binding protein 4 REGARDS Reasons for Geographic and Racial Differences in Stroke ROS reactive oxygen species SBIs silent brain infarcts SGLT2i sodium-glucose cotransporter-2 inhibitor STS sodium thiosulfate TABASCO Tel Aviv Brain Acute Stroke Cohort T1DM type 1 diabetes mellitus T2DM type 2 diabetes mellitus TGF- transforming growth factor- TNF- tumor necrosis factor- UACR urine albumin-to-creatinine ratio WMH white matter hyperintensities WMLs white matter lesions

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