96,97 Moreover, the ME1 protein is hypophosphorylated at S336 and hyperacetylated at K337 by PGAM family member 5 and acetyl-CoA acetyltransferase, respectively, resulting in ME1 translocation from mitochondria to the cytosol, dimerization and activation, thus strongly promoting NADPH generation and tumorigenesis
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In agreement, the amount of Cyclin D1 protein was strongly induced in the WT regenerating livers from 36 to 48 h prior the onset of DNA synthesis while its expression gradually increased in a time-dependent manner leading to the maximal levels after only 55 h in the Gstp1/2 / livers (Figures 5b and c)
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