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APS may phosphorylate IRS-1 by the phosphatidylinositol-3 kinase (PI3K)/protein kinase B (PKB, also known as Akt) signal pathway to promote the activation of the AMPK/acetyl-CoA carboxylase (ACC) pathway and its downstream targets, glycogen synthase kinase 3beta (GSK3), phosphoenolpyruvate carboxyl kinase (PEPCK), and gluconeogenic enzymes glucose 6-phosphatase (G6Pase) phosphorylation, to improve glucose metabolism (Sun et al., 2019)

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