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This checkpoint modulation creates permissive conditions for T cell-mediated tumor elimination and provides strong rationale for combining SFN with immune checkpoint inhibitors to overcome therapeutic resistance

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We also excluded studies that lacked a clear link between the functional ingredient and cancer mechanismsfor instance, purely observational epidemiological studies reporting correlations between diet and cancer outcomes without investigating any biological mechanism were not included

S2), and their combination was expected to improve reactivity and reduce off-target effects compared to a single nanobody 22

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