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Let the water run slowly down the inner glass wall of the vial never spray directly onto the lyophilized powder, as this can damage the peptide's tertiary structure

In contrast to EAE where the primary stimulus is immune upregulation in the presence of extrinsic myelin antigens, the CAE model illustrates that MS-like pathology can also be generated by an upstream intrinsic myelin injury, releasing antigens which secondarily trigger white matter inflammation in an immune-predisposed host

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