The pro-inflammatory triggers apparently increased TNF- and IL-6 release, while GHK-Cu apparently reduced both cytokines
However, metoclopramide carries a black-box warning for tardive dyskinesia with prolonged use (beyond 12 weeks), so it's reserved for short-term rescue during the worst escalation weeks
But promise without proof is hypothesis, not treatment
[3] This is a fundamentally different problem from that faced by single-agonist drugs, and it is why the class is sometimes described as polypharmacology in one molecule. A useful way to picture the balance problem is to imagine two dials on the same molecule
Of note, the dNK-like cell production of angiogenin and VEGF was dependent on STAT-3 and STAT-5 activation, whereas the production of MMP-9, TIMP-1, and TIMP-2 was STAT-3/5-independent (109)