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The key is to identify the exact pain generatorfor example a peripheral trigger point, scar, focal nerve entrapment or a neurovascular contactand, when appropriate, perform targeted interventions directly at that site (e.g., selective nerve blocks, trigger-point injections or very small, focused ablations)

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NNMT as Target (Kraus et al., 2014): NNMT knockdown in white adipose tissue and liver protected against diet-induced obesity by increasing cellular energy expenditure

The risk of adverse effects does not diminish with infrequent use