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Prior study has also identified N-acetyl cysteine ethyl ester (NACET), an esterified and lipophilic NAC prodrug, as a promising alternative for reducing intracellular ROS [22, 23]

Effective treatment begins with early nonpharmacologic measures such as physiotherapy, occupational therapy, and psychological support, followed by cautious introduction of pharmacologic options such as gabapentinoids, SNRIs, TCAs, and NAC based on patient response and tolerance level

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Preferential induction of apoptosis by interferon (IFN)- compared with IFN-2: correlation with TRAIL/Apo2L induction in melanoma cell lines