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Although most of the FRET applications in the early days were related to the estimation of distances between interacting partners, in 1978, Elisa Haas, Ephraim Katchalski-Katzir, and Izchak Z

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Explored as a possible aid for recovery and lean-mass preservation in frail or catabolic populations, though a Merck-sponsored Phase 2b trial in elderly hip-fracture patients (Adunsky et al., 2011, Archives of Gerontology and Geriatrics, PMID 21067829) was halted early over a cardiac safety signal rather than demonstrating a clear functional benefit

10.3389/fmicb.2016.00053 121 HozzeinW