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Results Administration of exogenous melatonin alleviates allergic airways disease severity in allergen-exposed mice Given the growing evidence linking circadian disruption to increased severity of allergic asthma ( Alternaria alternata (AA) or PBS daily for four days, with or without concurrent intraperitoneal melatonin treatment using established protocols described previously ( Figure 1A )

Additionally, gut microbiota enhances resistance to Streptococcus pneumoniae pneumonia and Klebsiella pneumoniae pneumonia via nucleotide-binding oligomerization domain protein 2 (NOD2) and granulocyte-macrophage colony-stimulating factor (GM-CSF) signaling pathways (52)

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Cystine/glutamate antiporter and aripiprazole compensate NMDA antagonist-induced dysfunction of thalamocortical L-glutamatergic transmission

Lactobacillus fermentum ME-3 produces another powerful antioxidant enzyme called manganese superoxide dismutase (MnSOD). MnSOD is the primary antioxidant enzyme in mitochondria which are the energy-producing sites within cells