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Recent reports suggest that lung macrophages are important orchestrators of the termination and resolution of inflammation and initiate parenchymal repair processes that are essential for a return to homeostasis with normal gas exchange [14, 15]

Urrutia et al., 2017

In the companys supplemental NDA, Neurocrine included data from the Phase III KINECT-HD trial and the ongoing KINECT-HD2 open-label study to establish the safety and efficacy of Ingrezza in the proposed indication

The inability to properly utilize L-carnitine and fatty acids creates a vicious, self-perpetuating cycle of oxidative stress and systemic inflammation that wreaks havoc across multiple organ systems

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