Compared to sgRNA controls, sg CBS significantly reduced intracellular cystathionine, cysteine, and GSH levels
Additionally, it has been demonstrated that also chronic hepatitis C virus (HCV) infection in hepatocyte cell lines led to a decreased levels of reduced GSH and a concomitant increase of oxidative stress ( The altered intracellular redox state has been envisaged as target for anti-influenza therapy, but also in this case the data arising from in vivo studies are inconsistent, and in some cases have indicated that antioxidants could exacerbate the disease
The difference is that these medications have undergone years of research and large-scale clinical trials before receiving regulatory approval
1 Introduction Psoriasis, a chronic inflammatory skin disease, affects an estimated 125 million individuals globally, with prevalence rates varying among ethnic groups, typically ranging from 0.33% to 0.6% (1)
doi: 10.3233/cbm-2005-1105