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In lung cancer models, AIFM2 overexpression was reported to enhance apoptosis in response to cytotoxic drug treatment 39

Though further research is necessary to better understand the underlying mechanism, it is evident that oxidative stress is implicated in the pathogenesis of or is at least systematically present in PN

An argument can therefore be made that the real ALD is actually the adrenomyeloneuropathic form, with the more aggressive cerebral ALD of young boys driven by a superimposed autoimmune inflammation that is secondary to the myelin lipid derangement

Biallelic mutations in ARMC12 cause asthenozoospermia and multiple midpiece defects in humans and mice

10.1016/j.freeradbiomed.2011.06.022 Free Radic