According to the study's authors, "Abundant evidence suggests that nicotine prevents vasodilatation of blood vessels and reduces blood flow, which impairs normal erectile function and negatively affects male sexual performance." The authors note that "Another plausible mechanism for the e-cigarette's association with erectile dysfunction is that exposure to e-cigarette refill liquids with or without nicotine reduces circulating testosterone levels (by 50% and 30%, respectively) owing to a decrease in the messenger RNA expression of 2 key steroidogenesis enzymes, cytochrome P450scc and 17b-hydroxysteroid dehydrogenases, at least in rodent models." "Moreover," according to the study's authors, human studies have shown a doseresponse association between the nicotine concentration in cigarettes and erectile dysfunction, with high-nicotine cigarettes being associated with higher rates of erectile dysfunction than low-nicotine cigarettes." So, the next time you see some super sexy-looking hunk bellowing e-cig vapor, remind youself, looks can be deceiving.
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