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Its only restriction is for people aged 18 or under, for pregnant or breastfeeding women, or for people with high nicotine intolerance

*Correspondence: Shikhar Shrestha, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

-blockers with additional vasodilatory effects, such as carvedilol and nebivolol, exhibit vasodilatory properties in addition to their beta receptors blocking effects (Northfield and Manallack, 2007

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