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While direct cortisol measurements were not specifically reported in the published safety trials, the comprehensive metabolic monitoring across 900+ participants showed no clinically significant hormonal changes, and the mechanism of action provides no pathway for cortisol stimulation

Hormonal fluctuations, particularly in females, can affect ligament laxity and susceptibility to injury, as variations in estrogen levels have been linked to changes in the mechanical properties of the ACL

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Furthermore, quality verification measures help researchers obtain materials that align with documented specifications and analytical requirements