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The two degradation pathways coexist and operate independently of one another, and have therefore distinct physiological significance and regulation

In its invasive hyphal form, Candida penetrates the intestinal epithelium and releases more than 70 identified mycotoxins including acetaldehyde, gliotoxin, and candidalysin that trigger systemic inflammation, impair mitochondrial function, disrupt neurotransmitter synthesis, and compromise the integrity of the gut barrier, producing a multi-system clinical presentation that spans gastrointestinal, neurological, endocrine, dermatological, and immunological domains

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These two systems that drive us to sleep are strongest around 2 am to 6 am and 2 pm to 6 pm

Credit: Brenda Darroch 2