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In addition, Matesanz-Snchez et al.s study showed that a decrease in EXT2 levels can cause dysregulation of lipid metabolism and antioxidant capacity by altering SAM and transsulfuration pathway enzymes levels, triggering lipid peroxidation and ultimately leading to ferroptosis in GBM cells [12]

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[28] Vitamin E supplements were found to significantly increase the risk of prostate cancer by 17% in healthy men compared with those who took a placebo

American women live, on average, five years longer than men