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Nutrients 12(7):1970

The common feature of leukemia-associated IDH1 and IDH2 mutations is a neomorphic enzyme activity converting alpha-ketoglutarate to 2-hydroxyglutarate

72 These astrocytes maintain their interactions with local neurones, synapses, oligodendrocytes and vascular cells but may alter these interactions in accordance with context-specific reactive changes in molecular expression and functions