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The global economic burden is substantial, with annual costs estimated at $20 - 30 billion, including $10 billion in direct healthcare costs and $15 - 20 billion in productivity losses due to disability (5)

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Grape seed extract contains oligomeric proanthocyanins (OPCs), an antioxidant

This could indicate that, while both conditions involve neurobiological changes, the patterns of alteration differ possibly reflecting distinct underlying mechanisms