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The pathophysiology of ADHD involves OS and neuroinflammation resulting from an imbalance between oxidants and antioxidants, catecholaminergic dysfunction, treatment-related effects, and environmental and genetic influences

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There are 3 main isoforms: ApoE2, ApoE3, and ApoE4 in humans which represent 8, 77, and 15% allelic frequency, respectively (Huang and Mahley, 2014)