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Since sickle cells have lower levels of arginase-1 activity than normal red blood cells do, nitric oxide cannot be created from scratch, especially in those who hemolyze often [37]

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Marked anisocytosis is often noted (reflected as a wide red blood cell size distribution on the electronic counter) because of the coexistence of large polychromatic cells and contracted cells, some of which can be frankly classified as spherocytes

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