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These two approaches substrate supplementation and enzyme inhibition can be considered conceptually complementary, but they are mechanistically distinct

Intestinal barrier dysfunction and dysbiosis can lead to translocation of bacterial lipopolysaccharide (LPS) and gut-derived toxins into the systemic circulation, triggering systemic low-grade inflammation ( Traditional nutritional management of DKD has primarily focused on single-nutrient interventions such as protein restriction, glycemic control, and blood pressure management

The neurodegenerative conditions caused due to HD lead to cognitive, motor, and psychiatric symptoms, atrophy of the basal ganglia and the cerebral cortex (Wright et al., 2017