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Impact: Positive Key areas of impact: Level of evidence: Preliminary Level of risk: Negligible How it works GHK-Cu chelates copper ions, enabling the activation of fibroblasts for more intensive production of collagen and glycosaminoglycans

Lin MI, Yu J, Murata T, Sessa WC

Effects Investigated in Research In the fields of endocrinology and cell biology, CJC-1295 no DAC is primarily studied for its ability to selectively bind to GHRH receptors in the anterior pituitary gland

113 A study comparing sleep hygiene therapy plus sleep restriction to sleep hygiene therapy alone found sleep restriction improved sleep efficiency

Interestingly, the study suggests that GHK-Cu might stimulate the secretion of TIMP-1 and TIMP-2, which are specific inhibitors of metalloproteinases, indicating a role in finely tuning the balance of matrix remodeling