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Outcomes relied on caregiver-reported behavioral and sleep questionnaires (CBCL, TBAQ-SF, Vineland-2, CSHQ, BISQ), analyzed using mixing effects regression models

Other factors that contribute to AD-related depressive behaviors include a deficiency in melatonin ( Aggressive behavior and related pathology in AD mouse models The rate of injurious behavior is increased in male 5xFAD mice when housed together, compared to wildtype or mixed genotype groups (Pugh et al., 2007