It directly inhibited the stearoyl-CoA desaturase-1 (SCD1) protein to trigger ferroptosis of ovarian cancer, evidenced by the increased ROS, total iron, and Fe 2+ levels and downregulation of ferroptosis inhibitors (SLC7A11 and GPX4), thus suppressing cancer progression in the SKOV-3 xenograft model (Liu et al., 2022)
282 Intriguingly, lactylation is involved in cardiac fibrosis and cardiac dysfunction following myocardial infarction
Key takeaways: Glutathione is produced in your cells and acts as a potent antioxidant, protecting cells from oxidative damage
[1] This enzymatic route the GSH mechanism most cited in redox biology is far more quantitatively significant than direct scavenging for handling peroxides
Ge P, Luo Y, Okoye CS, Chen H, Liu J, Zhang G, Xu C, Chen H