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and markers of thrombosis and endothelial cell activation including plasminogen activator inhibitor-1 (PAI-1), protein C, protein S, Von Willebrand factor (vWF), factor IX, intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion protein 1 (VCAM-1) (Fig

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Anisimov, V.N., et al., Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice

Behavioral measurements should primarily include the percentage of time spent in the open quadrant, the percentage of entries into the open quadrant, the number of times the animal peeks down from the edge of the platform while in the open or closed quadrant, and the number of stretch-attend postures from the closed quadrant to the open quadrant