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A reasonable titration schedule might look like this: Week 1: 200mcg once daily Week 2: 300mcg once daily Week 3 onward: 300-500mcg based on response and tolerance Optimizing injection technique Poor injection technique contributes to injection site reactions and potentially to other effects like nausea from anxiety around the process

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402 Different pharmacological methods have been applied to restore E/I imbalance, such as mGluR5 antagonist treatment, NMDAR agonist treatment and GABAR agonist treatment

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