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GPX4s activity depends on system xc, a widely distributed amino acid antiporter in the phospholipid bilayer consisting of a light chain subunit (solute carrier family 7A11, SLC7A11 ) and a heavy chain subunit (solute carrier family 3 member 2, SLC3A2 )

Ishii and Tycko, 2000

Moreover, these results of the multi-lineage differentiation capacity were validated by the upregulation of the FABP4 known as intracellular lipid chaperones, which regulate lipid trafficking and responses in cells [39,40], as well as PPAR critically involved in the regulation of a large number of genes, which regulate energy homeostasis, glucose triglyceride and lipoprotein metabolism, de novo lipogenesis, fatty acid uptake, oxidation, storage and export, cell proliferation, inflammation, and vascular tissue function [41]

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