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p53-pS15 is a major focal point in p53 activation to mediate p53-dependent transcription or growth arrest, Ser 15 phosphorylation triggers a sequence of additional sites phosphorylation in p53 (including Ser9, -20, -46 and Thr18) that contribute further to p53 activation 28

Patients with severe cardiac, hepatic, or renal disease should also avoid testosterone injections, as exogenous androgens may exacerbate edema and other complications in these conditions

These therapeutic approaches are currently regarded as experimental and off-label, and patients should be fully informed of the limited empirical support for their efficacy and safety in these contexts

There must be a mechanism by which a cell integrates all of these signals to determine its survival status

Proper loading, stability, and neuromuscular control still matter