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Tumor microenvironment remodeling Tumor cells reside in a highly heterogeneous niche composing of extracellular matrix and stromal cells such as fibroblasts, macrophages, and endothelial cells

MOTS-c is a mitochondrial-derived peptide with emerging evidence for metabolic optimization and longevity

Obesity 17 , 460466 (2009)

More specialised tests such as active B12 (holotranscobalamin) or methylmalonic acid may be available through specialist referral, though availability varies across the UK

Additionally, lifestyle interventions such as regular physical activity of minimum 150 min per week and pharmacological approaches as discussed in this review could further alleviate TMAO-related complications