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during chromosome replication, DNA-replicating enzymes cannot continue replication to the very end of the chromosome, so with each replication the chromosome end is shortened (this is because the synthesis of fragments requires the attachment of RNA primers to the lagging strand)

In a clinical trial, TB4 at a dose of 0.03% applied topically to venous ulcers led to complete wound healing in 33.3% of patients, compared to 23.5% for placebo

"Non-pyrogenic" just means it is made to be free of the leftovers that cause fevers

For this reason, combining CoQ 10 supplementations with other nutrients could potentially augment the clinical benefits in these situations [6,165,166,167]

If apoptosis is not induced, this is primary necrosis and the compound of interest is not a good candidate for cancer therapeutics