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10.1111/j.1749-6632.1995.tb17369.x 75 LanderosR

Docking studies with jr PPO1-wt revealed that the main driving force for the correct substrate orientation is the -stacking system established between the aromatic ring of the gatekeeper residue Phe260, the substrates aromatic ring and the imidazole group of the CuB coordinating His243 ( -stacking system: Phe260-substrate-His243) (Fig

Scientists have turned a number of peptides into safe and effective drugs, including insulin, which moves sugar from blood into cells, and GLP-1 (the P stands for peptide), which helps regulate appetite and is used in weight-loss medications such as Ozempic