To date, four primary types of PANoptosomes have been identified: the ZBP1-PANoptosome (comprising ZBP1, NLRP3, ASC, caspase-1, caspase-6, caspase-8, RIPK1 and RIPK3) [39], AIM2-PANoptosome (comprising AIM2, Pyrin, ZBP1, ASC, caspase-1, caspase-8, FADD, RIPK1 and RIPK3) [40], RIPK1-PANoptosome (comprising RIPK1, RIPK3, NLRP3, ASC, caspase-1 and caspase-8) [41] and NLRP12-PANoptosome (comprising NLRP12, ASC, caspase-8 and RIPK3) [42]
10.1007/S13659-023-00424-W [DOI] [PMC free article] [PubMed] [Google Scholar] Lecerf, J
Beyond this pathway, our GSEA analysis of the TCGA-HCC cohort indicated that high SLC25A39 expression positively enriches phosphatidylinositol 3-kinase (PI3K)/protein kinase B (AKT) and mammalian target of rapamycin complex 1 (mTORC1) signatures (Supplementary Fig
Quercetin was demonstrated to inhibit ferroptosis and improve joint cartilage destruction and degradation, delaying OA progression, by activating the AMP-activated protein kinase (AMPK)/Nrf2/GPX4 signaling pathway (Zhou et al., 2025a)
Regenerates Other Antioxidants Glutathione doesnt just fight oxidative stressit helps recycle and restore other antioxidants like vitamin C and E, keeping your antioxidant defense system stronger for longer
