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In contrast, a shorter period of RPM supplementation from day -7 to +7 relative to artificial insemination was not sufficient to affect calves birth and weaning weights or induce prenatal morphological alterations in the embryo and fetuses (Heredia et al, 2025a)

GHK-Cu upregulates genes involved in collagen synthesis, extracellular matrix assembly, and tissue remodeling while downregulating genes associated with tissue destruction (matrix metalloproteinases, inflammatory cytokines)

Therefore, the absence of TrkB signalling in iSPN + triggers severe energy deficits, possibly caused by mitochondrial dysfunction that suppresses OxPhos processes

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