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Consensus in favor of a statement was predefined as 70% of the respondents, with agreement categorized as strongly agree, mostly agree, or agree ( A third virtual meeting was subsequently convened to review the draft recommendations

However, subsequent well-designed, randomized, placebo-controlled clinical trials with NAC 600 mg three times daily, combined with other medications or in monotherapy failed to provide evidence supporting the use of NAC in patients with IPF [31] and identified safety issues with the combination of prednisone, azathioprine, and NAC [30]

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