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[92] A one-carbon (1C) methyl group is added to tetrahydrofolate through the action of serine hydroxymethyltransferase (SHMT) to yield 5,10-methylenetetrahydrofolate (5,10-CH 2 -THF)

Corticosteroid and NAC nasal douching significantly reduced symptom severity more than two-fold, resolved mucosal edema, and restored mucociliary function in recurrent acute rhinosinusitis patients compared to steroid with ambroxol, leading to better long-term satisfaction (121)

[DOI] [PubMed] [Google Scholar] 153.Renshall L.J., Morgan H.L., Moens H., Cansfield D., Finn-Sell S.L., Tropea T., Cottrell E.C., Greenwood S., Sibley C.P., Wareing M., et al

However, if you have sensitive skin, it is better to begin with a smaller concentration