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Global status report on noncommunicable diseases 2010

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We and others also demonstrated that hemin induces the expression of NRF2 in SCD erythroblasts and animal models and such effect is mitigated by administration of dimethyl fumarate (DMF) 23,24 , an FDA-approved drug for the treatment of multiple sclerosis

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doi: 10.1016/j.bbadis.2018.08.012 257 KaserSMoschenACayonAKaserACrespoJPons-RomeroFet al

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Concomitantly, recent studies have highlighted the ability of PA to induce ferroptosis in numerous cell types, such as cardiomyocytes [38], pancreatic -cells [37], and even colon cancer cells [32]

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However, Xu 2024 offers something Pei did not: detailed subgroup analyses by needle depth and treatment duration

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